Clinical Significance

Activated Partial Thromboplastin Time (APTT) is used for the evaluation of the intrinsic coagulation pathway, APTT substitution test, and the monitoring of heparin therapy. Prolonged clotting times may be observed in the following situations: deficiency of Factors II, V, VIII, IX, X , XI, XII or fibrinogen, liver diseases, vitamin K deficiency, presence of heparin, lupus anticoagulant or other inhibitor.

_{Source: HemosIL SynthASil PN 0020006800 IFU}