Clinical Significance

Vancomycin is a complex glycopeptide antibiotic, which is used for the treatment of infections caused by Gram‑positive organisms, primarily methicillin resistant Staphylococcus aureus (MRSA), coagulase‑negative Staphylococci, Streptococci or Enterococci, particularly in patients allergic to β‑lactams. 

Common side effects include, amongst others, the following: (a) red man syndrome, a histamine‑mediated flushing during or immediately following infusion, (b) nephrotoxicity, and (c) ototoxicity; the latter two adverse events are dose/level dependent. 

_{Source: Roche Cobas VANC4 Method Sheet Version 4.0 2023-11}