Clinical Significance

Salicylate is a common drug used in many formulations due to its analgesic and anti‑inflammatory properties. Salicylate overdose can cause metabolic acidosis with a high anionic gap, gastrointestinal and central nervous system disturbances, as well as encephalopathy and renal failure. Therefore, a method for the rapid and accurate determination of salicylate is needed. 

_{Source: Roche Cobas SALI Method Sheet Version 5.0 2024-05}