Clinical Significance

γ‑glutamyltransferase is used in the diagnosis and monitoring of hepatobiliary diseases. Enzymatic activity of GGT is often the only parameter with increased values when testing for such diseases and is one of the most sensitive indicators known. γ‑glutamyltransferase is also a sensitive screening test for occult alcoholism. Elevated GGT activities are found in the serum of patients requiring long-term medication with phenobarbital and phenytoin.

_{Source: Roche Cobas GGT-2 Method Sheet Version 2.0 2022-09}