Clinical Significance

D-Dimer is contained in the soluble derivatives formed upon plasmin degredation of Factor XIIIa cross-linked fibrin (XDP). These soluble fibrin degradation products contain neoantigen (D-Dimer domain), which is not present on the original fibrinogen molecule, its degradation products or on soluble fibrin. The determination of D-Dimer is becoming a widespread tool for diagnosing thrombosis and monitoring thrombolytic therapy. Elevated levels of D-Dimer are found in clinical conditions such as deep vein thrombosis (DVT), pulmonary embolism (PE), and disseminated intravascular coagulation (DIC). D-Dimer levels also rise during the normal pregnancy but very high levels are associated with complications. A negative D-Dimer result when combined with a clinical assessment of low pretest probability has been shown to have a high negative predictive value for DVT or PE.

_{Source: HemosIL D-Dimer HS 500 PN 0020500100 IFU}