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Test Code CDIFF Clostridioides difficile Toxin, EIA

Important Note

Up to 50% of neonates may be colonized with toxigenic C. difficile. Testing for C. difficile infection in this population should proceed only after consultation with the clinician. Specimens sent on patients under 1 year of age are rejected.

Infectious

Additional Codes

EPIC LAB4604

Purpose

For the simultaneous detection of Clostridioides difficile glutamate dehydrogenase antigen and toxins A and B

Methodology

Rapid membrane enzyme immunoassay (Alere Quik Chek)

Sample Type

Stool

 

***Stool must be liquid enough to pour or assume the shape of the container***

Specimen Minimum Volume

0.1 mL

Specimen Stability

Temperature Time
Ambient (18-25°C) 24 hours
Refrigerated (2-8°C) (store) 72 hours*

*If held longer than 72 hours, fecal specimens should be frozen at -10°C or below. Thaw at room temperature before running test and avoid freeze/thaw cycles.

Reference Ranges

Result Interpretation
Antigen Negative, Toxin Negative Specimen Negative for C. difficile
Antigen Positive, Toxin Positive Specimen Positive for C. difficile*
Antgien Positive, Toxin Negative Interpret results in conjunction with patient symptoms. If patient is symptomatic of C. difficile infection, treat as per protocol.

*Contact precautions

Rejection Criteria

  • Formed stool
  • Mislabeled specimens
  • Specimens collected on patients <1 year of age
  • Specimens preserved in 10% formalin or polyvinyl alcohol (PVA).

Availability

Performed STAT
Daily 0700 - 2030 Yes

Performing Laboratory

MultiCare Yakima Memorial Hospital Laboratory

Lab Department

Microbiology

CPT Code

87324

LOINC

79177-2 C. difficile glutamate dehydrogenase and toxins A+B IA.rapid QI

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